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KMID : 0669519930030000085
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Journal of Health Science - Yonsei University
1993 Volume.3 No. 0 p.85 ~ p.88
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A Study on Analysis of Urinany CS₂ Metabolites by HPLC
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Abstract
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The objective of this study is developing the optimal analytic methods for detecting urinary metabolites(2-thiothiazolidine-4-carboxylic acid, thiocarbamide) of carbon disulfide(CS2). The high performance liquid chromatography (HPLC) conditions(eluent;50mM KH₂-PO₄; Acetonitrile = 85:15, column;NH2 4.5× 25cm, flow rate;0.8ml/min) have been optimized by means of various experimentts. Ethyl acetate extraction method was adopted as precleaning method for HPLC analysis of urinary metabolites. The detection of TTCA and thiocarbamide by UV detector was more precise and accurate than that by RI detector.
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KEYWORD
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